Aim: This systematic review aims to evaluate the effect of acupressure in the management of cancer-related pain and anxiety.

Material and Methods: Science Direct, Web of Science, SCOPUS, Springer Link, Networked Digital Library of Theses & Dissertations, Ovid, CINAHL, Pubmed, Cochrane Library, Proquest, YÖK National Thesis Center, ULAKBIM databases were searched without year limitation. This systematic review has been prepared and presented according to the current Cochrane guidelines and PRISMA checklist.

Results: Six studies, four randomized controlled studies and two quasi-experimental studies, were included in this systematic review. In the studies included in the review, the frequency of application of acupressure in the management of pain was stated as every day, the session duration as 15 minutes, and the number of sessions as 4-42 sessions. The frequency of application of acupressure in the management of anxiety is stated as every day and throughout the day, since it is applied with a wristband, the session duration is 15-30 minutes, and the number of sessions is 5-42 sessions.

Conclusion: In this study, acupressure was found to have a positive effect in the management of cancer-related pain and anxiety. No adverse effect was reported in the included studies.